the parent compound and the hydroxyl metabolite possess in vitro antimicrobial activity. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. Vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Nursing Mothers Metronidazole is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels. Rx only Manufactured by: unichem laboratories LTD.
Vaginalis infection is a venereal disease. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. Effect of Dialysis, following a single intravenous infusion or oral dose of Metronidazole 500 mg, the clearance of Metronidazole was investigated in esrd subjects undergoing hemodialysis or continuous ambulatory peritoneal dialysis (capd). CNS symptoms are generally reversible within days to weeks upon discontinuation of Metronidazole. Searle division of Pfizer Inc. One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to Metronidazole in-utero; however, these findings were not confirmed. Drug/Laboratory Test Interactions Metronidazole may interfere with certain types of determinations of serum chemistry values, such as ny phil promo code aspartate aminotransferase (AST, sgot alanine aminotransferase (ALT, sgpt lactate dehydrogenase (LDH triglycerides, and glucose hexokinase. Metronidazole has shown mutagenic activity in in vitro assay systems including the Ames test. Drugs that Inhibit CYP450 Enzymes The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half-life and decrease plasma clearance of Metronidazole. Hypersensitivity: Urticaria, erythematous rash, Stevens-Johnson Syndrome, toxic epidermal necrolysis, flushing, nasal congestion, dryness of the mouth (or vagina or vulva and fever. Vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).
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